From Slices to Volumes: Comparing 2D, 2.5D, and 3D Residual Networks for Pulmonary Nodule Malignancy-Risk Classification

arXiv:2610.35960v1 Announce Type: new Abstract: Purpose: To compare 2D, 2.5D, and 3D residual networks for pulmonary nodule malignancy-risk classification and evaluate momentum-contrast pretraining, mild augmentation, and exclusion of indeterminate ratings. Methods: A retrospectively prepared LIDC-IDRI cohort contained 2,654 nodules labeled benign, indeterminate, or malignant using median radiologist ratings. Patient-disjoint splits comprised 1,876 training, 382 validation, and 396 test nodules. Representations included one axial slice, five neighboring slices, and a local CT volume. Each track evaluated a randomly initialized baseline, momentum-contrast pretraining followed by fine-tuning, and supervised training with mild augmentation. Checkpoints were selected by validation Macro-F1.