RIVER: Evidence-guided multi-agent retrieval for enzyme--reaction discovery

arXiv:2611.07757v1 Announce Type: new Abstract: Enzyme function annotation and the identification of candidate enzymes for a given reaction are essential steps in connecting genomic information to biochemical reaction networks. However, existing methods rely on sequence or structural similarity or on training with known enzyme--reaction pairs, making it difficult to integrate biochemical evidence across large candidate spaces; they also struggle with retrieval tasks involving enzyme families whose members are highly similar.