End-to-End Differentiable Diffusion Conditioning for Physics-Informed Optimization

arXiv:2610.31721v1 Announce Type: new Abstract: Optimizing high-dimensional physical systems under expensive evaluations and complex constraints is a central challenge in science and engineering. In offline model-based optimization (MBO), methods must improve designs using only a fixed dataset and no test-time access to the true objective. However, existing methods typically suffer from conservatism, unconstrained surrogate exploitation, or function as static inference-time samplers that cannot refine candidates against precise physical objectives. In this paper, we propose Differentiable Diffusion Conditioning (D2C) for offline MBO, which leverages the fact that deterministic sampling makes the reverse denoising chain differentiable with respect to the conditioning signal.